The TRIM13 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TRIM13. This antibody recognizes Human antigen. The TRIM13 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor